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Although photothermal therapy (PTT) overcomes the awkward situation of antibiotic resistance, it usually mistakenly kills the beneficial bacteria strains when eliminating pernicious bacteria. Specifically recognizing and damaging the target pathogens is urgently required for PTT\u2010mediated sterilization strategy. Based on the host\u2013guest recognition between cucurbit[10]uril (CB[10]) and porphyrins, two water\u2010soluble supramolecular porphyrins are designed and implement selective bactericidal effect via in situ bacteria\u2010responsive near\u2010infrared (NIR) PTT. With the help of CB[10], the \u03c0\u2013\u03c0 stacking and hydrophobic interactions of porphyrins are efficiently inhibited, thus contributing to a good photostability and a high photothermal conversion efficiency. Attributing to the matching reduction potential between facultative anaerobic <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) and porphyrins, they are selectively in situ reduced into supramolecular phlorin and supramolecular chlorin by <jats:italic>E. coli<\/jats:italic>, successfully achieving a selective sterilization against <jats:italic>E. coli<\/jats:italic>. In vivo, the in situ bacteria\u2010responsive NIR PTT systems also promote the quick recovery of <jats:italic>E. coli<\/jats:italic>\u2010infected abscesses and trauma on mice without inducing obvious systemic toxicity, providing a new alternative to the current antibiotics and helping relieve the global public health crisis of abusive antibiotics.<\/jats:p>","DOI":"10.1002\/adhm.202401662","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T13:36:09Z","timestamp":1728567369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Supramolecular Porphyrin Photosensitizers Based on Host\u2212Guest Recognition for In Situ Bacteria\u2010Responsive Near\u2010Infrared Photothermal Therapy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-9258","authenticated-orcid":false,"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou 310014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlong","family":"Du","sequence":"additional","affiliation":[{"name":"Bethune First Clinical Medical College Jilin University  Changchun 130012 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Department of Science and Technology  Taiyuan 030021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou 310014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunmin","family":"Ping","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering Zhejiang University of Technology  Hangzhou 310014 P. R. 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