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SCNPs are ultrasmall polymeric nanoparticles with sizes similar to proteins, making them ideal for biomedical applications. Amphiphilic SCNPs result from the self\u2010assembly in water of isolated synthetic polymeric chains through intrachain hydrophobic interactions, mimicking natural biomacromolecules and, specially, proteins (in size and when loaded with drugs, metal ions or fluorophores also in function). These ultrasmall, soft nanoparticles have various applications, including catalysis, sensing, and nanomedicine. Initial in vitro experiments with nonfunctionalized, amphiphilic SCNPs loaded with a photosensitizing Zn phthalocyanine with four nonperipheral isobutylthio substituents, ZnPc, showed promise for PDT. Herein, the preparation of improved, amphiphilic SCNPs containing ZnPc as highly efficient photosensitizer encapsulated within the nanoparticle and surrounded by anthracene units is disclosed. The amount of anthracene groups and ZnPc molecules within each single\u2010chain nanoparticle controls the imaging and PDT properties of these nanocarriers. Critically, this work opens the way to improved PDT applications based on amphiphilic SCNPs as a first step toward ideal, long\u2010term artificial photo\u2010oxidases (APO).<\/jats:p>","DOI":"10.1002\/adhm.202401683","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T02:21:01Z","timestamp":1720405261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Amphiphilic Single\u2010Chain Polymer Nanoparticles as Imaging and Far\u2010Red Photokilling Agents for Photodynamic Therapy in Zebrafish Embryo Xenografts"],"prefix":"10.1002","volume":"13","author":[{"given":"Davide","family":"Arena","sequence":"first","affiliation":[{"name":"Centro de F\u00edsica de Materiales (CSIC, UPV\/EHU) and Materials Physics Center MPC  Paseo Manuel Lardizabal 5 Donostia 20018 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron Universit\u00e9 de Montpellier CNRS ENSCM  Montpellier 34293 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiaa M. 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