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In particular, sarcopenia, aging\u2010related degenerative muscle loss, necessitates urgent remedies. Current approaches for treating muscle atrophy include exercise and nutrition, while drug exploration remains in its early stages. Cell therapy, focusing on satellite cells, faces significant challenge due to poor engraftment, safety issue, and high cost. Cell\u2010free approach using extracellular matrix (ECM) shows a regenerative potential, but a lack of mechanical and adhesive properties hinders prolonged efficacy of ECM therapy. Here, durable muscle ECM (MEM) hydrogels for muscle atrophy by fortifying MEM with adhesive phenolic moieties including catechol and pyrogallol are demonstrated. The resultant phenolic MEM hydrogels exhibit enhanced mechanical and adhesive properties and provide sustained muscle\u2010like microenvironments to address muscle atrophy. No local and systemic toxicities are observed after phenolic MEM injection into tibialis anterior muscle. Notably, these engineered MEM hydrogels, devoid of cells or drugs, induce tissue rejuvenation by promoting muscle protein synthesis and facilitating functional muscle recovery in mouse models of disuse\u2010 and age\u2010induced atrophy. This study introduces cell\u2010free, ECM\u2010based therapeutics with translational potential for muscle atrophy by reversing muscle loss and restoring function.<\/jats:p>","DOI":"10.1002\/adhm.202401826","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:46:22Z","timestamp":1729219582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy"],"prefix":"10.1002","volume":"13","author":[{"given":"Soojeong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"},{"name":"CellArtgen Inc.  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Yonsei University  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsu","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang\u2010Ung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Yonsei University  Seoul 03722 Republic of Korea"},{"name":"Center for Nanomedicine Institute for Basic Science (IBS)  Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-332X","authenticated-orcid":false,"given":"Seung\u2010Woo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University  Seoul 03722 Republic of Korea"},{"name":"CellArtgen Inc.  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