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The repair healing of chronic diabetic wounding is tremendously hindered due to persistent inflammatory reaction. To address the aforementioned issues, here, a dual\u2010functional hydrogel is designed, consisting of N1\u2010(4\u2010boronobenzyl)\u2010N3\u2010(4\u2010boronophenyl)\u2010N1, N1, N3, N3\u2010tetramethylpropane\u20101, 3\u2010diaminium (TSPBA) modified polyvinyl alcohol (PVA) and methacrylamide carboxymethyl chitosan (CMCSMA) can not only electrostatically adsorb proinflammatory cytokines of IL1\u2010\u03b2 and TNF\u2010\u03b1, but can also chemically scavenge the excessive reactive oxygen species (ROS) in situ. Both in vitro and in vivo evaluations verify that the negatively charged and ROS\u2010responsive hydrogel (NCRH) can effectively modulate the chronic inflammatory microenvironment of diabetic wounds and significantly enhance wound remodeling. More importantly, the well\u2010designed NCRH shows a superior skin recovery in comparison with the commercial competitor product of wound dressing. Consequently, the current work highlights the need for new strategies to expedite the healing process of diabetic wounds and offers a wound dressing\u00a0material with immunomodulation.<\/jats:p>","DOI":"10.1002\/adhm.202402080","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T03:06:36Z","timestamp":1728443196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Immunomodulatory Hydrogel for Electrostatically Capturing Pro\u2010inflammatory Factors and Chemically Scavenging Reactive Oxygen Species in Chronic Diabetic Wound Remodeling"],"prefix":"10.1002","volume":"13","author":[{"given":"Zihao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery Shenzhen Children's Hospital  Shenzhen 518038 China"},{"name":"Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology  Wuhan 430074 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