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This study introduces a novel supramolecular guanosine\u2010phenylboronic\u2010chlorogenic acid (GBC) hydrogel developed using a dynamic covalent strategy. The hydrogel forms through guanosine quadruplex assembly in the presence of potassium ions and chlorogenic acid (CA) linkage via dynamic borate bonds. GBC hydrogels exhibit pH and glucose responsiveness, releasing more chlorogenic acid under acidic and high glucose conditions due to borate bond dissociation and G\u2010quadruplex (G4)\u00a0hydrogel disintegration. Experimental results indicate that GBC hydrogels exhibit good self\u2010healing, shear\u2010thinning, injectability, and swelling properties. Both in vitro and in vivo studies demonstrate the GBC hydrogel's good biocompatibility, ability to eliminate bacteria and reactive oxygen species (ROS), facilitate macrophage polarization from the M1 phenotype to the M2 phenotype (decreasing CD86 expression and increasing CD206 expression), exhibit anti\u2010inflammatory effects (reducing TNF\u2010\u03b1 expression and increasing IL\u201010 expression), and promote angiogenesis (increasing VEGF, CD31, and \u03b1\u2010SMA expression). Thus, GBC hydrogels accelerate DFU healing and enhance tissue remodeling and collagen deposition. This work provides a new approach to developing responsive hydrogels to expedite DFU healing.<\/jats:p>","DOI":"10.1002\/adhm.202402092","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T08:30:15Z","timestamp":1725352215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Novel Supramolecular Hydrogel for Infected Diabetic Foot Ulcer Treatment"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenbiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Second Affiliated Hospital of Anhui Medical University Hefei Anhui 230601 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia The First Affiliated Hospital of Anhui Medical University North district Anhui Public Health Clinical Center Hefei Anhui 230011 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