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Guided tissue regeneration techniques, particularly barrier membranes, enable local regeneration by providing an isolated, protected compartment for osseous wound healing while excluding epithelial tissue. Here, this study reports on a thermosensitive periodontal membrane (TSPM) technology designed to overcome the mechanical limitations of current membranes through a semi\u2010interpenetrating network of high molecular weight poly(L\u2010lactic acid) (PLLA) and in situ\u2010polymerized mesh of poly(\u03b5\u2010caprolactone)diacrylate (PCL\u2010DA), and poly lactide\u2010co\u2010glycolide diacrylate (PLGA\u2010DA). An optimized composition allows facile reshaping at greater than 52 \u00b0C and rigid shape maintenance at physiological temperature. Its unique bilayer morphology is achieved through self\u2010assembly and thermally\u2010induced phase separation, resulting in distinct yet continuous smooth and nanofibrous compartments adequate for epithelial occlusion and regeneration. Incorporating PLGA\u2010DA enhances the membrane's hydrophilicity and degradation properties, facilitating a more rapid and controlled degradation and therapeutic delivery. This study demonstrates its ability to promote local regeneration by serving as a barrier membrane and simultaneously as a scaffolding matrix in a rat orthotopic periodontal defect model. The TSPM outperformed a clinically available material (Epi\u2010Guide) to facilitate robust alveolar bone and periodontal ligament regeneration at 4 and 8 weeks.<\/jats:p>","DOI":"10.1002\/adhm.202402137","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:21:43Z","timestamp":1729729303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthetic Periodontal Guided Tissue Regeneration Membrane with Self\u2010Assembling Biphasic Structure and Temperature\u2010Sensitive Shape Maintenance"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-7117","authenticated-orcid":false,"given":"W. 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