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However, there are no accessible digital tools for wearable and continuous monitoring of corneal oxygen and microenvironment status. Here, a kirigami\u2010inspired breathable smart contact lens for wireless monitoring of corneal hypoxia and microenvironment is presented. The ultrathin (55 \u00b5m) and flexible sensing device enables digitalized, in situ and precise monitoring of key eye health indicators: dissolved oxygen, humidity, and temperature (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    &gt; 0.98). The flexible circuit, designed and processed using evolutionary kirigami structures and thermoforming, efficiently conforms to the soft curved surfaces with minimized contour dimensions and residual stress. Silicone\/hydrogel hybrid layers encapsulate the electronics, achieving high oxygen permeability (380.26 Barrers), sufficient water content (&gt;80%), and excellent biocompatibility\/heat safety. In vivo animal experiments in beagle eyes demonstrate the lens's capability for accurate, wireless corneal monitoring under controlled conditions.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202402148","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:08:41Z","timestamp":1748243321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Kirigami\u2010Inspired Breathable Smart Contact Lens for Wireless Monitoring of Corneal Hypoxia and Microenvironment"],"prefix":"10.1002","volume":"14","author":[{"given":"Jiaxue","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"AML Department of Engineering Mechanics Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"Institute of Flexible Electronics Technology of THU  Zhejiang Jiaxing 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"Institute of Flexible Electronics Technology of THU  Zhejiang Jiaxing 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University  Chengdu 610031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Solid Mechanics Beihang University (BUAA)  Beijing 100191 China"},{"name":"Tianmushan Laboratory Xixi Octagon City  Yuhang District Hangzhou 310023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Engineering Mechanics Zhejiang University  Hangzhou Zhejiang 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"Institute of Flexible Electronics Technology of THU  Zhejiang Jiaxing 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Jiao","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"},{"name":"Beijing Ophthalmology &amp; Visual Sciences Key Lab Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"},{"name":"Beijing Ophthalmology &amp; Visual Sciences Key Lab Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"},{"name":"Beijing key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"},{"name":"Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology Beijing Tongren Hospital Capital Medical University  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"AML Department of Engineering Mechanics Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-8474","authenticated-orcid":false,"given":"Xue","family":"Feng","sequence":"additional","affiliation":[{"name":"Laboratory of Flexible Electronics Technology Tsinghua University  Beijing 100084 China"},{"name":"AML Department of Engineering Mechanics Tsinghua University  Beijing 100084 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.04.001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12192"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000481"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071398"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70178-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-198208000-00003"},{"key":"e_1_2_9_8_1","first-page":"371","volume":"43","author":"Bonanno J. 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