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Excessive oxidative stress and increased susceptibility to bacterial infection are key issues that impede diabetic wound healing. Cerium oxide nanoparticles (CeO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) have attracted increasing attention because of their unique antioxidant and antimicrobial properties. Here, this work designs a near\u2010infrared (NIR) light\u2010responsive gelatin methacryloyl (GelMA)\/CeO\n                    <jats:sub>2<\/jats:sub>\n                    \/polydopamine (PDA) hydrogel with antibacterial and antioxidant effects. The hydrogel exhibits a stable, efficient, and controllable photothermal conversion capacity under NIR stimulation. The hydrogel can be used to construct a local microenvironment conducive to chronic diabetic wound healing. Significant antibacterial effects of the NIR\u2010responsive GelMA\/CeO\n                    <jats:sub>2<\/jats:sub>\n                    \/PDA hydrogel on both\n                    <jats:italic>Escherichia coli (E.coli)<\/jats:italic>\n                    and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) are demonstrated by counting colony\u2010forming units (CFUs) and in bacterial live\/dead staining experiments. The strong antioxidant activity of hydrogels is demonstrated by measuring the level of reactive oxygen species (ROS). The effect of the NIR\u2010responsive GelMA\/CeO\n                    <jats:sub>2<\/jats:sub>\n                    \/PDA hydrogel in terms of promoting diabetic wound healing is validated in full\u2010thickness cutaneous wounds of diabetic rat models. Additionally, this work describes the mechanism by which the NIR\u2010responsive GelMA\/CeO\n                    <jats:sub>2<\/jats:sub>\n                    \/PDA hydrogel promotes diabetic wound healing; the hydrogel inhibits the interleukin (IL)\u201017 signaling pathway. This NIR\u2010responsive, multifunctional hydrogel dressing provides a targeted approach to diabetic wound healing.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202402236","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:46:35Z","timestamp":1736390795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Multifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Yijia","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Peking University School and Hospital of Stomatology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1898","authenticated-orcid":false,"given":"Yunsong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology  Beijing 100081 China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&amp; Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3887"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c23461"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01371"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202000632"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11040"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b03656"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101072"},{"key":"e_1_2_8_3_4","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206771"},{"key":"e_1_2_8_3_5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202211811"},{"key":"e_1_2_8_3_6","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203306"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S276001"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad040"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.215"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b03513"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700973"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092399"},{"key":"e_1_2_8_5_5","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00294"},{"key":"e_1_2_8_5_6","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c01792"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c12012"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119936"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.577557"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194559"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100033"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.061"},{"key":"e_1_2_8_10_1","volume":"13","author":"Xue Y.","year":"2023","journal-title":"Adv. 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