{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:45:13Z","timestamp":1791521113389,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810100"],"award-info":[{"award-number":["2023YFB3810100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Decellularized artificial blood vessels prepared using physical and chemical methods often exhibit limitations, including poor mechanical performance, susceptibility to inflammation and calcification, and reduced patency. Cross\u2010linking techniques can enhance the stiffness, as well as anti\u2010inflammatory and anti\u2010calcification properties of decellularized vessels. However, conventional cross\u2010linking methods fail to effectively alleviate residual stress post\u2010decellularization, which significantly impacts the patency and vascular remodeling following the implantation of artificial vessels. This study enhances vascular residual stress through varied conditions of proanthocyanidin (PC) cross\u2010linking on decellularized vessels. Microstructural analysis and mechanical investigations across various scales of fresh, decellularized, and residual stress\u2010recovered vessels are performed using atomic force microscopy (AFM), scanning electron microscopy (SEM), and uniaxial tensile testing. Results demonstrate substantial alterations in the morphology of elastic and collagen fibers post\u2010decellularization, which remarkably resemble fresh vessels following residual stress recovery. Furthermore, both the micro\u2010 and macro\u2010mechanical characteristics of vessels post\u2010residual stress recovery, including Young's modulus, viscoelasticity, and adhesion, closely resemble those of fresh vessels. Finite element modeling (FEM) confirms the distribution of residual stress and its role in enhancing vascular mechanical integrity. This experimental investigation provides a theoretical foundation at both micro and macroscopic levels for the development of biomimetic blood vessels.<\/jats:p>","DOI":"10.1002\/adhm.202402250","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T03:02:43Z","timestamp":1736737363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Multiscale Mechanical Study of Proanthocyanidins for Recovering Residual Stress in Decellularized Blood Vessels"],"prefix":"10.1002","volume":"14","author":[{"given":"Yibo","family":"Han","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering  Chongqing 400044 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering  Chongqing 400044 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Omondi","family":"Ochieng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering  Chongqing 400044 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanrui","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 100037 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Central Hospital of Chongqing University Chongqing Emergency Medical Center  Chongqing 400014 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering  Chongqing 400044 P. R. China"},{"name":"JinFeng Laboratory  Chongqing 401329 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-7502","authenticated-orcid":false,"given":"Zhiyi","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology (Chongqing University) Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants College of Bioengineering  Chongqing 400044 P. R. China"},{"name":"JinFeng Laboratory  Chongqing 401329 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw334"},{"key":"e_1_2_8_2_1","first-page":"81","volume":"3","author":"Hu K.","year":"2022","journal-title":"Biomater. Transl."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15143003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aabd56"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.06.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2008.06.161"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9142864"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-018-0170-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.046"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.08.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"J.Vesely L.Horny H.Chlup M.Krajicek R.Zitny presented at6th European Conf. of the Int. Federation for Medical and Biological Engineering2015 7 399.","DOI":"10.1007\/978-3-319-11128-5_100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918753"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaa058"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12481"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.02.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.01.028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.11.037"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42254-018-0001-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR06753A"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202100159"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317685"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.740"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b00314"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10861"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.04.152"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-010-3986-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.018"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02584301"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4038704"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03185274"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104906"},{"key":"e_1_2_8_33_1","volume-title":"The Contribution of Elastin, Collagen, and Smooth Muscle Cells to the Biomechanics of Large Elastic Arteries","author":"Wang J.","year":"2004"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10255842.2016.1183125"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00483C"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00444-X"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202402250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:08:52Z","timestamp":1759774132000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202402250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/adhm.202402250"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202402250","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"2024-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2402250"}}