{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:26:28Z","timestamp":1788261988643,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302391,U20A20260,82272162"],"award-info":[{"award-number":["82302391,U20A20260,82272162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bacterial infection\u2010induced excessive inflammation is a major obstacle in diabetic wound healing. Nitric oxide (NO) exhibits significant antibacterial activity but is extremely deficient in diabetes. Hence, a near\u2010infrared (NIR)\u2010triggered NO release system is constructed through codelivery of polyarginine (PArg) and gold nanorods (Au) in an NIR\u2010activatable methylene blue (MB)\u00a0polypeptide\u2010assembled nanovesicle (Au\/PEL\u2010PBA\u2010MB\/PArg). Upon NIR irradiation, the quenched MB in the nanovesicles is photoactivated to generate more reactive oxygen species (ROS) to oxidize PArg and release NO in an on\u2010demand controlled manner. With the specific bacterial capture of phenylboronic acid (PBA), NO elevated membrane permeability and boosted bacterial vulnerability in the photothermal therapy (PTT) of the Au nanorods, which is displayed by superior mild PTT antibacterial activity against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) at temperatures\u00a0&lt;\u00a049.7\u00a0\u00b0C in vitro. Moreover, in vivo, the antibacterial nanovesicles greatly suppressed the burst of MRSA\u2010induced excessive inflammation, NO relayed immunomodulated macrophage polarization from M1 to M2, and the excessive inflammatory phase is successfully transferred to the repair phase. In cooperation with angiogenesis by NO, tissue regeneration is accelerated in MRSA\u2010infected diabetic wounds. Therefore, nanoplatform has considerable potential for accelerating the healing of infected diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202402297","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T05:39:36Z","timestamp":1724391576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Near Infrared\u2010Triggered Nitric Oxide\u2010Release Nanovesicles with Mild\u2010Photothermal Antibacterial and Immunomodulation for Healing MRSA\u2010Infected Diabetic Wounds"],"prefix":"10.1002","volume":"13","author":[{"given":"Chang","family":"Xu","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound the First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan 250000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danting","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhe","family":"Yan","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Tianjin University of Technology  Tianjin 300384 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of bioactive materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongwei","family":"Qu","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College  Tianjin 300192 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-5842","authenticated-orcid":false,"given":"Jimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Functional Polymers, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Chemical Engineering and Technology Hebei University of Technology  Tianjin 300130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0252-y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105152"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.017"},{"key":"e_1_2_10_5_1","first-page":"284","volume":"21","author":"Ye J.\u2010J.","year":"2022","journal-title":"Bioact. 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