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Natural enzymes can be used as biological agents for the treatment of oxidative stress\u2010related diseases, but limiting to catalytic and environmental stability as well as high cost. Herein, an artificial enzyme, gold nanoclusters (Au NCs) with excellent stability, bioactivity, and renal clearance can be used as the next\u2010generation biological agents for acute lung injury (ALI) and allergic lung disease (ALD). The Au<jats:sub>25<\/jats:sub> clusters can mimic catalase (CAT) and glutathione peroxidase (GPx), and the K<jats:sub>m<\/jats:sub> of Au<jats:sub>24<\/jats:sub>Er<jats:sub>1<\/jats:sub> with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> reaches 1.28\u00a0mM, about 22 times higher than natural CAT (\u224828.8\u00a0mM). The clusters inhibit the oxidative stress in the mitochondria and promote the synthesis of adenosine triphosphate (ATP). The molecular mechanism shows that the TLR4\/MyD88\/NF\u2010\u03baB pathway and M1 macrophage\u2010mediated inflammatory response are suppressed in ALI and the Th1\/Th2 imbalance in ovalbumin (OVA)\u2010induced ALD is rescued. Further, the clusters can notably improve lung function in both ALI and ALD models which paves the way for immunomodulation and intervention for lung injury and can be used as a substitute for natural enzymes and potential biopharmaceuticals in the treatment of various types of pneumonia.<\/jats:p>","DOI":"10.1002\/adhm.202402364","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T06:02:45Z","timestamp":1725861765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Atomic Artificial Enzyme for Acute and Chronic Pneumonia"],"prefix":"10.1002","volume":"14","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Brain Science and Neural Engineering Academy of Medical Engineering and Translational Medicine Tianjin University  Tianjin 300072 China"},{"name":"Tianjin Key Laboratory of Birth Defects for Prevention and Treatment 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