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The \u03b2\u2010lactamase (Bla) secreted by methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) hydrolyzes nearly all \u03b2\u2010lactam antibiotics, leaving only a few antibiotics available for the clinical treatment of MRSA infections. Thereby, a Bla\u2010responsive peptide (BLAP) is designed here with the capacity of inhibiting MRSA infection through mimicking the host defense mechanism of human defensin\u20106. The BLAP comprising a self\u2010assembling peptide sequence can respond specifically to the secreted Bla and assemble in situ surrounding MRSA. The assembled nanofibrous network is able to trap MRSA, preventing its invasion into the host cells effectively. As a consequence, the intramuscular injection of BLAP significantly restricted bacterial infection and abscess formation in mice. The biomimetic BLAP holds great potential for the efficient treatment of drug\u2010resistant gram\u2010positive bacterial infections.<\/jats:p>","DOI":"10.1002\/adhm.202402453","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:15:01Z","timestamp":1723180501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A \u03b2\u2010Lactamase Responsive Peptide Inhibits MRSA Infection through Self\u2010Assembled Nanonet"],"prefix":"10.1002","volume":"13","author":[{"given":"Minghao","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxing","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"},{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cong","sequence":"additional","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-0833","authenticated-orcid":false,"given":"Yejiao","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Shanghai University  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-3021","authenticated-orcid":false,"given":"Honggang","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai 200444 China"},{"name":"Shanghai Engineering Research Center of Organ Repair  Shanghai 200444 China"},{"name":"Shanghai Integration and Innovation Center of Marine Medical Engineering  Shanghai 200444 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c03909"},{"key":"e_1_2_9_1_2","first-page":"5","volume":"1","author":"Wang Y.","year":"2023","journal-title":"Interdiscip. 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