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The condition is worsened by oxidative stress, which heightens inflammation and perpetuates a cycle of damage that current treatments only temporarily relieve. To address this, a novel treatment involving the in situ crystallization of ultrasmall cerium oxide nanoparticles (\u22483\u00a0nm) on mesenchymal stem cell (MSC) extracellular vesicles (EVs) for the management of primed mycobacterial uveitis (PMU) is developed. This nanohybrid leverages the individual and synergistic effects of its components for a comprehensive therapeutic approach. The cerium oxide nanoparticles act as a nanozyme to reduce inflammation and scavenge excessive reactive oxygen species (ROS), while the MSC EVs, with their biocompatibility, modulate inflammatory cell infiltration and alleviate tissue damage. This synergistic system offers a promising new treatment strategy for ocular diseases characterized by oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/adhm.202402523","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T06:08:25Z","timestamp":1729663705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In Situ Crystallized Ceria\u2010Vesicle Nanohybrid Therapeutic for Effective Treatment of Inflammatory Intraocular Disease"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-4676","authenticated-orcid":false,"given":"Jiawei","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Beijing Chaoyang Hospital Capital Medical University  Beijing 100020 P. R. 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