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Tissue\u2010engineered corneas have demonstrated potential as corneal equivalents. Nevertheless, the development of adhesive corneal patches and full\u2010thickness corneal substitutes remains challenging. In this study, a multifunctional hydrogel corneal patch (MHCP) is constructed by integrating a dual\u2010crosslinked hybrid hydrogel with temperature and light responsiveness with a natural extracellular matrix scaffold. When applied to the ocular surface, MHCP spontaneously releases adhesives at body temperature and forms a stable adhesion with the recipient cornea through photocuring. In addition to its inherent mechanical, optical, and ultrastructural characteristics, which are similar to those of the natural stroma, MHCP demonstrates excellent suture resistance, anti\u2010swelling, and anti\u2010degradation properties after curing. MHCP promotes the proliferation and migration of corneal epithelial cells in vitro and maintains the phenotype of corneal stromal cells. In vivo, MHCP maintains graft hydration and restores corneal structural integrity and transparency during penetrating keratoplasty of various sizes and sutureless lamellar keratoplasty. Collectively, given the advantages of native stroma\u2010like characteristics, operation\u2010facilitating multiple functions, and convenient preparation, MHCP is a promising corneal substitute for clinical applications.<\/jats:p>","DOI":"10.1002\/adhm.202402567","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T03:17:52Z","timestamp":1731986272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Natural Extracellular Matrix Scaffold\u2010Based Hydrogel Corneal Patch with Temperature and Light\u2010Responsiveness for Penetrating Keratoplasty and Sutureless Stromal Defect Repair"],"prefix":"10.1002","volume":"14","author":[{"given":"Long","family":"Zhao","sequence":"first","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Shi","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqian","family":"Dou","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Sun","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Yang","sequence":"additional","affiliation":[{"name":"Binzhou Medical University  Binzhou 264003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University Eye Hospital of Shandong First Medical University (Shandong Eye Hospital)  Jinan 250021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-373X","authenticated-orcid":false,"given":"Weiyun","family":"Shi","sequence":"additional","affiliation":[{"name":"Eye Institute of Shandong First Medical University State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.12.037"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_1942_23"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12635"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2019.05.009"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.10.020"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205878"},{"key":"e_1_2_9_5_1","volume":"29","author":"Shi W.","year":"2019","journal-title":"Adv. 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