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The current landscape of transparent electrode technology faces challenges in developing durable, highly transparent electrodes while maintaining low interface impedance and prioritizing scalable processing and fabrication methods. To address these limitations, we introduce artifact\u2010resistant transparent MXene microelectrode arrays optimized for high spatiotemporal resolution recording of neural activity. With 60% transmittance at 550 nm, these arrays enable simultaneous imaging and electrophysiology for multimodal neural mapping. Electrochemical characterization shows low impedance of 563 \u00b1 99 k\u03a9 at 1 kHz and a charge storage capacity of 58 mC cm\u207b\u00b2 without chemical doping. In vivo experiments in rodent models demonstrate the transparent arrays' functionality and performance. In a rodent model of chemically\u2010induced epileptiform activity, we tracked ictal wavefronts via calcium imaging while simultaneously recording seizure onset. In the rat barrel cortex, we recorded multi\u2010unit activity across cortical depths, showing the feasibility of recording high\u2010frequency electrophysiological activity. The transparency and optical absorption properties of Ti\u2083C\u2082Tx MXene microelectrodes enable high\u2010quality recordings and simultaneous light\u2010based stimulation and imaging without contamination from light\u2010induced artifacts.<\/jats:p>","DOI":"10.1002\/adhm.202402576","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T04:43:23Z","timestamp":1727412203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Transparent MXene Microelectrode Arrays for Multimodal Mapping of Neural Dynamics"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-5036","authenticated-orcid":false,"given":"Sneha","family":"Shankar","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia PA 19104 USA"},{"name":"Center for Neuroengineering &amp; Therapeutics University of Pennsylvania  Philadelphia PA 19104 USA"},{"name":"Center for Neurotrauma Neurodegeneration and Restoration Corporal Michael J. 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