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However, identifying a high\u2010performance strategy with good efficiency and low toxicity is still urgently needed. Antibacterial photodynamic therapy (PDT) is considered a non\u2010invasive and efficient approach with minimal drug resistance. Whereas, the precise molecular design for highly efficient oxygen\u2010independent type\u2010I photosensitizers is still undefined. In this work, the regulation of the positive charge of star\u2010shaped NIR\u2010emissive organic photosensitizers can boost radical generation for the efficient treatment of wounds infected with multidrug\u2010resistant bacteria. With positive charge engineering, TPAT\u2010DNN, which has six positive charges, mainly produces hydroxyl radicals via the type\u2010I pathway, while TPAT\u2010DN, which has three positive charges, tends to generate singlet oxygen and superoxide radicals. For multidrug\u2010resistant bacteria, TPAT\u2010DNN exhibited specific killing effects on multidrug\u2010resistant gram\u2010positive bacteria at low concentrations, while TPAT\u2010DN is similar antibacterial effects on both multidrug\u2010resistant gram\u2010negative and gram\u2010positive bacteria. Furthermore, the efficiency and safety of TPAT\u2010DNN for eradicating multidrug\u2010resistant bacteria methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA) infection and accelerating wound healing in an MRSA\u2010infected mouse model are demonstrated. This work offers a new approach toward manipulating efficient type\u2010I photosensitizers for MRSA treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202402615","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T01:46:23Z","timestamp":1733708783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Charge Engineering of Star\u2010Shaped Organic Photosensitizers Enables Efficient Type\u2010I Radicals for Photodynamic Therapy of Multidrug\u2010Resistant Bacterial Infection"],"prefix":"10.1002","volume":"14","author":[{"given":"Jie","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Soochow University  Suzhou 215123 P. R. 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