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Herein, the study harnesses the intrinsic pro\u2010neural differentiation potential of nerve\u2010derived extracellular matrix (NDEM) and its specific affinity for cytokines to develop an NDEM\u2010gelatin methacryloyl(gelMA)\u2010based bifunctional hydrogel delivery system for stem cells and cytokines. This system promotes the neural differentiation of bone marrow stromal cells (BMSCs) and optimizes the therapeutic index of Interleukin\u20104 (IL\u20104) for spinal cord injury (SCI) treatment. It is observed that incorporating NDEM into the hydrogel system intrinsically promotes BMSC differentiation into neuron\u2010like cells and effectively regulates IL\u20104 release kinetics to match the neural reconstructing timeframe. Further analysis reveals that trace amounts of endogenous basic fibroblast growth factor (bFGF) detected in NDEM exhibit a potent effect in promoting neural differentiation. 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