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The diversity in venom composition between various types of snakes necessitates the use of different specific antivenom treatments, which presents clinical and financial challenges in the management of snakebites. Therefore, developing a broad\u2010spectrum antidote to neutralize complex and diverse snake venoms has assumed critical importance. Herein, a broad\u2010spectrum antidote is developed through molecular recognition and coassembly to neutralize four kinds of snake venom toxins, those are three\u2010finger toxin (3FTx), snake venom metalloproteinase (SVMP), phospholipase A<jats:sub>2<\/jats:sub> (PLA<jats:sub>2<\/jats:sub>), and snake venom serine protease (SVSP), which have high abundance and toxicity. The coassembly of sulfonate\u2010modified amphiphilic calixarene (SCA) and amphiphilic cyclodextrin (CD) is employed to neutralize the toxicity of 3FTx, 1,2\u2010dodecanedithiol (DDT) and thioetheramide phosphorylcholine (TEAPC) are introduced through coassembly to neutralize toxicity of SVMP and PLA<jats:sub>2<\/jats:sub>, respectively, and the nafamostat (NT), which can be loaded through the host\u2010guest complexation, is employed to neutralize toxicity of SVSP. The broad\u2010spectrum antidote, NT@SCA\/CD\/DDT\/TEAPC, effectively neutralizes key toxins from the most medically important cobra and vipers, significantly improving survival rates of poisoned mice. This study conceptually validated the feasibility of broad\u2010spectrum detoxification and also offers a conveniently integrated supramolecular strategy.<\/jats:p>","DOI":"10.1002\/adhm.202402732","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T03:56:07Z","timestamp":1733284567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Broad\u2010Spectrum Detoxification of Snake Venoms With Supramolecular Materials Integrated via Molecular Recognition and Coassembly"],"prefix":"10.1002","volume":"14","author":[{"given":"Meng\u2010Meng","family":"Chen","sequence":"first","affiliation":[{"name":"College of Chemistry State Key Laboratory of Elemento\u2010Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and Engineering Nankai University  Tianjin 300071 P. 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