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Prior research indicates a substantial association among MI, thrombosis, and the activation of oxidative stress pathways. The effectiveness of current thrombolytic drugs is relatively constrained, and the need for innovative and versatile thrombolytic medications remains critical. Nattokinase (NK) is a naturally\u2010occurring enzyme known for its thrombolytic characteristics. Nonetheless, nattokinase's limited stability and susceptibility to inactivation in biological systems have impeded its clinical utility. This study designs a manganese oxide nanozyme (MnOx) loaded with NK (MnOx@NK), which exhibits both antioxidant and thrombolytic function. The administration of MnOx@NK through tail vein injection significantly restores vascular function and further reduces myocardial injury in a mouse model of myocardial infarction, demonstrating a pronounced protective effect against oxidative stress. These findings indicate that nattokinase\u2010loaded nanozymes can be a promising approach for treating acute myocardial infarction, providing a new strategy for clinical application.<\/jats:p>","DOI":"10.1002\/adhm.202402763","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:26:41Z","timestamp":1734316001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Nattokinase\u2010Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation"],"prefix":"10.1002","volume":"14","author":[{"given":"Yingchao","family":"Shi","sequence":"first","affiliation":[{"name":"Fuwai Central\u2010China Cardiovascular Hospital Central China Fuwai Hospital of Zhengzhou University  Zhengzhou 450046 China"},{"name":"National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Central China Subcenter of National Center for Cardiovascular Diseases 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