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The previous attempt fabricated first\u2010generation nanobombs (nanobomb1G) by self\u2010assembly of polymeric NIR\u2010II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) to inhibit the expression of HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) is developed by self\u2010assembling small molecular NIR\u2010II AIEgens with CO carrier polymer PLGA(CO) coated by PEG\u2010lipid. This design allows for intravenous administration, enabling the SNB to circulate safely in the bloodstream and selectively target cancer cells. Upon accumulation in tumors, the SNB releases CO to effectively suppress HSP expression, enhancing the therapeutic efficacy of mild\u2010temperature PTT. Compared to the previous generation, the SNB offers a safer, more stable, and more efficient CO gas\/drug co\u2010delivery system for cancer treatment. This work represents a significant advancement in PTT, providing a promising strategy for enhanced antitumor therapy with reduced systemic toxicity.<\/jats:p>","DOI":"10.1002\/adhm.202402767","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:18:14Z","timestamp":1728555494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Precision Photothermal Therapy at Mild Temperature: NIR\u2010II Imaging\u2010Guided, H<sub>2<\/sub>O<sub>2<\/sub>\u2010Responsive Stealth Nanobomb"],"prefix":"10.1002","volume":"14","author":[{"given":"Gongcheng","family":"Ma","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Xinxiang Medical University  Xinxiang 453003 P. R. 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