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Hypochlorous acid (HOCl) is confirmed to be a reliable biomarker to extend the scope of diagnosis. However, the practical applications of the developed conjugated small molecule fluorescent probes for detecting HOCl are often restricted to a large extent by their low solubility, aggregation\u2010caused quenching (ACQ), unsatisfactory fluorescence brightness, small Strokes\u2010shift, and lack of self\u2010correcting ratiometric emitters. In this study, a J\u2010aggregation\u2010induced organic fluorescent dot (PBT dots), is reported which is facilely developed by co\u2010assembling newly designed organic molecule PBT with polymer DSPE\u2010PEG, for ClO<jats:sup>\u2212<\/jats:sup> imaging in living brain\u2010derived Endothelial (bEnd.3) cells and brain tissues of AD mice. The developed two\u2010photon PBT dots show NIR emission at 715\u00a0nm, large Stokes\u2010shift of 245\u00a0nm, quick response within 2\u00a0s, ratiometric sensing properties, and favorable blood\u2010brain barrier (BBB) penetrate ability. The results demonstrate that HOCl level is elevated in AD mouse brain, and PBT dot holds promise as an imaging probe to understand and reveal AD pathologies.<\/jats:p>","DOI":"10.1002\/adhm.202402779","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:06:43Z","timestamp":1732846003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Near\u2010Infrared Two\u2010Photon J\u2010Aggregation\u2010Induced Organic Fluorescent Dots with Large Stokes\u2010Shift for Ratiometric Imaging of Hypochlorous Acid in Living Cells and Brains of AD Mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Rui","family":"Huang","sequence":"first","affiliation":[{"name":"Anhui Provincial Key Laboratory of Biomedical Materials and Chemical Measurement Laboratory of Functionalized Molecular Solids Ministry of Education College of Chemistry and Materials Science Anhui Normal University  Wuhu 241002 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