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Despite surgery being a primary option, it often leads to incomplete removal and high recurrence rates. Photodynamic therapy (PDT) holds promise as an adjunctive treatment, but safety concerns and the need for high\u2010power lasers have limited its widespread use. This research addresses these challenges by introducing a novel PDT approach, using chlorin e6 (Ce6) enclosed in nanostructured lipid carriers (Ang\u2010Ce6\u2010NLCs) and targeted to GBM with the angiopep\u20102 peptide. Remarkably, a single 5\u2010min irradiation session with LEDs at 660\u00a0nm and low power density (10\u00a0mW cm<jats:sup>\u2212<\/jats:sup><jats:sup>2<\/jats:sup>) proves effective against GBM, while reducing safety risks associated with high\u2010power lasers. Encapsulation improves Ce6 stability and performance in physiological environments, while angiopep\u20102 targeting enhances delivery to GBM cells, maximizing treatment efficacy and minimizing off\u2010target effects. 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