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Vertically and horizontally samples are realized by LPBF with four surface finishing conditions (as\u2010built, corundum\u2010sandblasted, zirconia\u2010sandblasted, femtosecond laser textured). Bioactivity in vitro tests are performed with human osteoblasts evaluating morphology, metabolic activity, and differentiation capabilities in direct contact with surfaces. Scanning electron microscope and profilometry analysis are used to evaluate surface morphology and samples\u2019 roughness with and without cells. All tested surfaces show good biocompatibility. The influence of material surface features is evident in the early evaluation, with the most promising results of morphological study for laser texturing. Deposition orientations seem to influence metabolic activities, with XZ orientation more effective than XY. Current data provide the first positive feedback on the biocompatibility of laser texturing finishing, still poorly described in the literature, and support the future clinical development of devices produced with a combination of LPBF and different finishing treatments.<\/jats:p>","DOI":"10.1002\/adhm.202402873","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T08:59:36Z","timestamp":1729587576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biological Characterization of Ti6Al4V Additively Manufactured Surfaces: Comparison Between Ultrashort Laser Texturing and Conventional Post\u2010Processing"],"prefix":"10.1002","volume":"14","author":[{"given":"Maria","family":"Sartori","sequence":"first","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-0038","authenticated-orcid":false,"given":"Chiara","family":"Bregoli","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE) (Consiglio Nazionale delle Ricerche \u2013 CNR)  Via Gaetano Previati, 1\/E Lecco 23900 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Carniato","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cavazza","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Maglio","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Giavaresi","sequence":"additional","affiliation":[{"name":"Surgical Sciences and Technologies IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alberto","family":"Biffi","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE) (Consiglio Nazionale delle Ricerche \u2013 CNR)  Via Gaetano Previati, 1\/E Lecco 23900 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE) (Consiglio Nazionale delle Ricerche \u2013 CNR)  Via Gaetano Previati, 1\/E Lecco 23900 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Gruppioni","sequence":"additional","affiliation":[{"name":"INAIL Centro Protesi  Via Rabuina 14, Vigorso di Budrio Bologna 40054 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausonio","family":"Tuissi","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter Chemistry and Technologies for Energy (ICMATE) (Consiglio Nazionale delle Ricerche \u2013 CNR)  Via Gaetano Previati, 1\/E Lecco 23900 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Fini","sequence":"additional","affiliation":[{"name":"Scientific Direction IRCCS Istituto Ortopedico Rizzoli  Via Di Barbiano, 1\/10 Bologna 40136 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"1","volume":"15","author":"Xu J.","year":"2022","journal-title":"Materials (Basel)"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202000116"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5301\/jabfm.5000371"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40735-022-00700-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2021.11.084"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmapro.2021.02.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2021.104712"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17531934231193880"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5863-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2021.102223"},{"key":"e_1_2_8_12_1","first-page":"115","author":"Brogini S.","year":"2021","journal-title":"J. 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