{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:08:59Z","timestamp":1785892139390,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208320087"],"award-info":[{"award-number":["202208320087"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023731","name":"Consejer\u00eda de Salud y Consumo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CEX2023\u2010001303\u2010M funded by MICIU\/AEI\/ 10.13039\/501100011033"],"award-info":[{"award-number":["CEX2023\u2010001303\u2010M funded by MICIU\/AEI\/ 10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100023731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003989","name":"Ikerbasque, Basque Foundation for Science","doi-asserted-by":"publisher","award":["COLLAB22\/05"],"award-info":[{"award-number":["COLLAB22\/05"]}],"id":[{"id":"10.13039\/501100003989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003989","name":"Ikerbasque, Basque Foundation for Science","doi-asserted-by":"publisher","award":["GIU21\/033"],"award-info":[{"award-number":["GIU21\/033"]}],"id":[{"id":"10.13039\/501100003989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13GW0098"],"award-info":[{"award-number":["13GW0098"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13GW0099"],"award-info":[{"award-number":["13GW0099"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Replicative senescence presents a significant challenge in mesenchymal stem cell (MSC) expansion due to high reactive oxygen species (ROS) levels generated during culture. Elevated ROS levels lead to oxidative stress, cellular damage, and senescence, limiting the biomedical applications of MSCs. In this study, a supramolecular thermo\u2010reversible hydrogel composed of the natural polyphenolic compound gallic acid (GA) and polyvinyl alcohol (PVA) was designed to scavenge ROS and mitigate MSC senescence. The PVA\u2010GA hydrogel, stabilized by strong hydrogen bonding forces, exhibited an elastic modulus comparable to that of human soft tissue and facilitated the sustained release of GA over 14 days. It enhanced MSC survival, protected against oxidative stress, reduced intracellular ROS levels, diminished mitochondrial damage, and decreased cellular senescence. The hydrogel maintained the multilineage differentiation potential and typical phenotype of MSCs. Additionally, it preserved vascular endothelial growth factor (VEGF) secretion from MSCs under oxidative stress and enhanced their pro\u2010angiogenic effect. The conditioned medium derived from MSCs in the hydrogel group promoted migration and tube formation of human umbilical vein endothelial cells (HUVECs). These findings suggest that the PVA\u2010GA hydrogel holds significant promise for the biomedical applications of MSCs, potentially addressing the challenges posed by oxidative stress and cellular senescence.<\/jats:p>","DOI":"10.1002\/adhm.202402882","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:05:12Z","timestamp":1744884312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Antioxidant and Anti\u2010Senescence Polyvinyl Alcohol\u2010Gallic Acid Supramolecular Hydrogels for Stem Cell Culture"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-7595","authenticated-orcid":false,"given":"Yiduo","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Biochemistry Free University of Berlin  14195 Berlin Germany"},{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3454-5992","authenticated-orcid":false,"given":"Mat\u00edas L.","family":"Picchio","sequence":"additional","affiliation":[{"name":"POLYMAT, Applied Chemistry Department, Faculty of Chemistry University of the Basque Country UPV\/EHU  Paseo Manuel de Lardiz\u00e1bal 3 20018 Donostia\u2010San Sebasti\u00e1n Spain"},{"name":"IKERBASQUE Basque Foundation for Science  Plaza Euskadi 5 Bilbao 48009 Spain"},{"name":"Universidad Tecnol\u00f3gica Nacional Facultad Regional Villa Mar\u00eda  Av. Universidad 450 (5900) Villa Mar\u00eda C\u00f3rdoba Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Godoy Cruz 2290, CABA Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-0574","authenticated-orcid":false,"given":"Yan","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8005-277X","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Free University of Berlin  14195 Berlin Germany"},{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-0619","authenticated-orcid":false,"given":"Oihane","family":"Sanz","sequence":"additional","affiliation":[{"name":"POLYMAT, Applied Chemistry Department, Faculty of Chemistry University of the Basque Country UPV\/EHU  Paseo Manuel de Lardiz\u00e1bal 3 20018 Donostia\u2010San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-9979","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-854X","authenticated-orcid":false,"given":"Xun","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-2499","authenticated-orcid":false,"given":"Lukas","family":"Prantl","sequence":"additional","affiliation":[{"name":"Department of Plastic, Hand and Reconstructive Surgery University Hospital Regensburg  Franz\u2010Josef\u2010Strau\u00df\u2010Allee 11 93053 Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-5841","authenticated-orcid":false,"given":"Oliver","family":"Felthaus","sequence":"additional","affiliation":[{"name":"Department of Plastic, Hand and Reconstructive Surgery University Hospital Regensburg  Franz\u2010Josef\u2010Strau\u00df\u2010Allee 11 93053 Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-885X","authenticated-orcid":false,"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-9742","authenticated-orcid":false,"given":"Marcelo","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"POLYMAT, Applied Chemistry Department, Faculty of Chemistry University of the Basque Country UPV\/EHU  Paseo Manuel de Lardiz\u00e1bal 3 20018 Donostia\u2010San Sebasti\u00e1n Spain"},{"name":"IKERBASQUE Basque Foundation for Science  Plaza Euskadi 5 Bilbao 48009 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-1003","authenticated-orcid":false,"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Free University of Berlin  14195 Berlin Germany"},{"name":"Institute of Active Polymers Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"},{"name":"Institute of Functional Materials for Sustainability Helmholtz\u2010Zentrum Hereon  14513 Teltow Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1634782"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-021-10231-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10369-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01134-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1137947"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141883"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170622110654"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0771"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00601-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094642"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.03.034"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c22565"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0484"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113435"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2989076"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065508"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144351"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312641"},{"key":"e_1_2_8_19_1","volume":"14","author":"Gao J.","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.02.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA01911G"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-021-00872-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122880"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1162202"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01925J"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(02)00145-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201900217"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00935"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0PY01036G"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000119"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05222-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4489"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00891B"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1910668117"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics9010023"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1376799"},{"key":"e_1_2_8_37_1","first-page":"1595","volume":"32","author":"Russell L. H.","year":"2012","journal-title":"Anticancer Res."},{"key":"e_1_2_8_38_1","author":"Davalli P.","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02993-x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918755391"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.11.010"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413384"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01839-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v13.i11.1714"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.211"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002213"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.827900"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00364"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3893"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16361"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.235184.113"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.389"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.291"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-2-209"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01910-5"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12111470"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67289-8"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202402882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:45:11Z","timestamp":1759783511000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202402882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":59,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/adhm.202402882"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202402882","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2402882"}}