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In this study, cerium oxide nanoparticles (CeNPs) are encapsulated within a silk fibroin\u2010poly(e\u2010caprolactone) polymer to create an electrospun PSF\/CeNPs nanofiber membrane (PSF\/membrane). This membrane is further modified through the addition of an angiopoietin\u20101 mimetic peptide, QHREDGS, resulting in the formation of QPSF\/CeNPs (QHREDGS modified PSF\/CeNPs membrane). In vitro assessments revealed that the QPSF\/CeNPs displayed the intended ability to regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment and growth, exhibited anti\u2010inflammatory properties through the modulation of macrophage phenotypes from M1 to M2, as well as pro\u2010angiogenetic and antibacterial effects. In vivo, the membrane dressing demonstrated an acceleration of burn wound healing, promotion of angiogenesis, downregulation of inflammatory factors, and enhancement of collagen deposition. This bioactive membrane dressing shows potential as a clinical therapy for promoting the regeneration of both acute and chronically damaged skin tissue.<\/jats:p>","DOI":"10.1002\/adhm.202402886","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T23:41:06Z","timestamp":1733355666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bioactive Nanoparticle\u2010Embedded Micro\/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing"],"prefix":"10.1002","volume":"14","author":[{"given":"Lerong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Affiliated Hospital of Guilin Medical University  Guilin Guangxi 541000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, International Joint Laboratory on Regeneration of Bone and Soft Tissues Guangxi Key Laboratory of Regenerative Medicine &amp; 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