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The targeted PEG NPs incorporating targeting molecules of hyaluronic acid are engineered via the templating of metal\u2013organic frameworks, which can circumvent accelerated blood clearance and exhibit prolonged circulation time as well as improved accumulation of therapeutics at tumor sites. The targeted delivery of mitoxantrone under laser radiation induces immunogenic cell death of tumor cells, which is combined with toll\u2010like receptor 7\/8 agonists of imidazoquinoline to trigger immune responses of cytotoxic T lymphocytes for the eradication of tumor cells. Furthermore, the treatment can induce tumor\u2010specific immune responses that inhibit metastatic lung tumor growth. This reported targeted PEG NPs provide a rational design for cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/adhm.202402954","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:03:41Z","timestamp":1734314621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeting of Low\u2010Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal\u2010Enhanced Immunotherapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Mengqi","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University  Jinan 250100 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University  Jinan 250100 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University  Jinan 250100 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanaparedu P. 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