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Herein, inflammation\u2010targeting biomimetic nano\u2010decoys (TFMN) is developed that inhibit the infiltration of immune cells and effectively deliver glucocorticoids to lesions for enhanced MS treatment. Nano\u2010decoys encapsulated with the glucocorticoid methylprednisolone (MPS) are prepared by coating neutrophil membrane (NM) on nanoparticles formed by the self\u2010assembly of tannic acid and poloxamer188\/pluronic68. Benefiting from the natural inflammation\u2010targeting ability of activated neutrophil membranes, TFMN can target the lesion site and prevent neutrophils infiltration by adsorbing and neutralizing elevated neutrophil\u2010related cytokines, subsequently modulating the inflammatory microenvironment in experimental autoimmune encephalomyelitis mice. TFMN exhibits a strong antioxidant capacity and scavenged excessive reactive oxygen species to enhance neuronal protection. Furthermore, at the inflammation site, perforin, discharged by cytotoxic T\u2010lymphocytes, triggered the controlled release of MPS within the TFMN through perforin\u2010formed pores in the NM. Simultaneously, this mechanism protected neurons from perforin\u2010induced toxicity. The MPS liberated at the targeted site achieves optimal drug accumulation, thereby enhancing therapeutic efficacy. In conclusion, the innovative system shows potential for integrating various therapeutic agents, offering a novel strategy for CNS disorders.<\/jats:p>","DOI":"10.1002\/adhm.202402965","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T06:08:37Z","timestamp":1729663717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inflammation\u2010Targeted Biomimetic Nano\u2010Decoys via Inhibiting the Infiltration of Immune Cells and Effectively Delivering Glucocorticoids for Enhanced Multiple Sclerosis Treatment"],"prefix":"10.1002","volume":"14","author":[{"given":"Yiling","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Zhengzhou University  Zhengzhou 450052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of 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