{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:14:53Z","timestamp":1790190893211,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215243\/Z\/19\/Z"],"award-info":[{"award-number":["215243\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20843"],"award-info":[{"award-number":["20843"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intra\u2010articular glucocorticoid injections are effective in controlling inflammation and pain in arthritides but restricted by short duration of action and risk of joint degeneration. Controlled drug release using biocompatible hydrogels offers a unique solution, but limitations of in situ gelation restrict their application. Gellan sheared hydrogels (GSHs) retain the advantages of hydrogels, however their unique microstructures lend themselves to intra\u2010articular application \u2013 capable of shear thinning under force but restructuring at rest to enhance residence. This study examined GSHs for extended intra\u2010articular glucocorticoid delivery of prednisolone (10 mg\u00a0mL<jats:sup>\u22121<\/jats:sup>); demonstrating links between material mechanics, steroid release, and preclinical assessment of efficacy in synoviocyte culture and transgenic(TNF)197Gkl (TNFtg) murine model of arthritis. GSHs demonstrated sustained release, with typical Fickian profiles over 18 days. Moreover, systems showed good stability under extended culture, with inherent cell\u2010compatibility and suppression of inflammatory synoviocyte activation. In TNFtg animals, GSHs suppressed synovitis (70.08%, <jats:italic>p<\/jats:italic> &lt; 0.05), pannus formation (45.01%, <jats:italic>p<\/jats:italic> &lt; 0.05), and increased articular cartilage (82.23%, <jats:italic>p<\/jats:italic> &lt; 0.05) relative to vehicle controls. The extended profile of steroid release from injectable GSH formulations holds promise in the treatment and management of inflammatory arthritides such as rheumatoid and osteoarthritis, representing a step\u2010change in intra\u2010articular drug delivery to suppress long\u2010term joint inflammation.<\/jats:p>","DOI":"10.1002\/adhm.202403000","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T06:41:17Z","timestamp":1734936077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra\u2010Articular Space"],"prefix":"10.1002","volume":"14","author":[{"given":"Ana","family":"Crastin","sequence":"first","affiliation":[{"name":"Dept of Biomedical Sciences. Institute of Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Dept of Metabolism and Systems Science University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Suresh","sequence":"additional","affiliation":[{"name":"Dept of Biomedical Sciences. Institute of Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Davies","sequence":"additional","affiliation":[{"name":"Centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kearns","sequence":"additional","affiliation":[{"name":"Centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"},{"name":"Liver Services Unit Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsen","family":"Parlak","sequence":"additional","affiliation":[{"name":"Dept of Biomedical Sciences. Institute of Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Adcock","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filer","sequence":"additional","affiliation":[{"name":"Dept of Inflammation and Aging University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon W.","family":"Jones","sequence":"additional","affiliation":[{"name":"MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Raza","sequence":"additional","affiliation":[{"name":"Dept of Inflammation and Aging University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard JA","family":"Moakes","sequence":"additional","affiliation":[{"name":"Healthcare Technologies Institute School of Chemical Engineering University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam M.","family":"Grover","sequence":"additional","affiliation":[{"name":"Healthcare Technologies Institute School of Chemical Engineering University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-6739","authenticated-orcid":false,"given":"Rowan S.","family":"Hardy","sequence":"additional","affiliation":[{"name":"Dept of Biomedical Sciences. Institute of Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-022-00226-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905877"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.6.571"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3397-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190341"},{"key":"e_1_2_10_7_1","first-page":"203","volume":"6","author":"Pirkle S.","year":"2022","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13314"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ostima.2023.100157"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24131"},{"key":"e_1_2_10_11_1","volume":"8","author":"Lei L.","year":"2022","journal-title":"Gels"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081644"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym10050480"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-018-0138-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.103595"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705013"},{"key":"e_1_2_10_18_1","author":"Li J.","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120782"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-018-0061-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-8130(99)00091-4"},{"key":"e_1_2_10_23_1","volume":"11","author":"Mircioiu C.","year":"2019","journal-title":"Pharmaceutics"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218493"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/8\/3\/035004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010240"},{"key":"e_1_2_10_27_1","first-page":"110","volume":"60","author":"Peppas N. A.","year":"1985","journal-title":"Pharm Acta Helv"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34650"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.06.084"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02765-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8110723"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040411"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14713"},{"key":"e_1_2_10_34_1","first-page":"1082","volume":"36","author":"Henriksen M.","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.049"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110702"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevApplied.5.044020"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121802"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01083-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.01.005"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn4048205"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967115581163"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/00913847.2016.1168272"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-011-1820-6"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1972-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8080488"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.07.009"},{"key":"e_1_2_10_48_1","volume":"25","author":"Liu S.","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112303"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09325"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2012.12.009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2012.12.002"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb04978.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4806"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/discim\/kyac010"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/0023677217707985"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202403000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T19:00:36Z","timestamp":1759777236000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202403000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/adhm.202403000"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202403000","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]},"assertion":[{"value":"2024-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2403000"}}