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However, it is usually accompanied by a high incidence of fusion failure and pseudoarthrosis, placing higher demands on bone implants. Therefore, materials with good biocompatibility, osteoconductivity, and even induce bone ingrowth, which can be used to improve spinal fusion rate and bone regeneration, have become a hot research topic. Here, ultra\u2010small cerium oxide nanoparticles (CeO<jats:sub>2<\/jats:sub> NPs) are prepared and loaded onto the surface of the homograft bone surface to prepare a composite scaffold AB@PLGA\/CeO<jats:sub>2<\/jats:sub>. The composite scaffold shows the competitive ability to promote osteoblast differentiation in vitro. In vivo experiments show that AB@PLGA\/CeO<jats:sub>2<\/jats:sub> has a good bone enhancement effect. In particular, good biological effects of collagen fiber formation, osteogenic mineralization, and tissue repair are shown in intervertebral implant fusion. Further, transcriptome sequencing confirms that CeO<jats:sub>2<\/jats:sub> NPs promote osteogenic differentiation and mineralization by regulating extracellular matrix (ECM) and collagen formation. Meanwhile, CeO<jats:sub>2<\/jats:sub> NPs can regulate the function of the PI3K\u2010Akt signaling pathway to exert its ability to promote osteogenic differentiation and mineralization and affect p53 and cell cycle signaling pathway to regulate osteogenic differentiation and mineralization. Hence, the proposed scaffold is a promising strategy for intervertebral fusion in the clinic.<\/jats:p>","DOI":"10.1002\/adhm.202403006","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:41:28Z","timestamp":1730868088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Composite Scaffold Materials of Nanocerium Oxide Doped with Allograft Bone: Dual Optimization Based on Anti\u2010Inflammatory Properties and Promotion of Osteogenic Mineralization"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-9902","authenticated-orcid":false,"given":"Yuqiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Peking University People's Hospital  Beijing 100044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkang","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Tianjin Key Lab for Rare Earth Materials and Applications Nankai University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences Anhui Normal University  Anhui 241000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Luo","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Long","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"},{"name":"Department of Spine Surgery The Central Hospital of Shaoyang  Hunan 422000 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Peking University People's Hospital  Beijing 100044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Peking University People's Hospital  Beijing 100044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayi","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Tianjin Key Lab for Rare Earth Materials and Applications Nankai University  Tianjin 300350 China"},{"name":"Shanghat Zhitong Construction Engineering Tethnology Co, LTD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Du","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Tianjin Key Lab for Rare Earth Materials and Applications Nankai University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin Medical University  Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Peking University People's Hospital  Beijing 100044 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyun","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Tianjin Key Lab for Rare Earth Materials and Applications Nankai University  Tianjin 300350 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2003558"},{"key":"e_1_2_8_2_1","volume":"16","author":"Goodman S. 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