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However, current hydrophilic polymer coatings and films have significant drawbacks, including swelling and delamination. To address these issues, hydroxyethyl cellulose is modified with thioether groups to generate an oxidation\u2010responsive polymer, HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    . HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    readily dissolves in green solvents and can be fabricated as coatings or films with tunable thicknesses. HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    coatings effectively scavenge hydrogen peroxide, resulting in the conversion of thioether groups to sulfoxide groups on the polymer chain. Oxidation\u2010driven, hydrophobic\u2010to\u2010hydrophilic transitions that are isolated to the surface of HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    coatings under physiologically relevant conditions increase wettability, decrease stiffness, and reduce protein adsorption to generate a non\u2010fouling interface with minimal coating delamination or swelling. HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    can be used in diverse optical applications and permits oxidation\u2010responsive, controlled drug release. HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    films are non\u2010resorbable in vivo and evoke minimal foreign body responses. These results highlight the versatility of HEC\n                    <jats:sub>MTP<\/jats:sub>\n                    and support its incorporation into chronically implanted medical devices.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403021","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T02:39:22Z","timestamp":1732761562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thioether\u2010Functionalized Cellulose for the Fabrication of Oxidation\u2010Responsive Biomaterial Coatings and Films"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-3060","authenticated-orcid":false,"given":"Eric M.","family":"DuBois","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-3798","authenticated-orcid":false,"given":"Kate E.","family":"Herrema","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4434-0007","authenticated-orcid":false,"given":"Matthew G.","family":"Simkulet","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-9867","authenticated-orcid":false,"given":"Laboni F.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-970X","authenticated-orcid":false,"given":"Payton R.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"},{"name":"Department of Biomedical Engineering Rensselaer Polytechnic Institute  Troy NY 12180\u20103590 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-9870","authenticated-orcid":false,"given":"Riya","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Boston University  Boston MA 02215\u20102407 USA"},{"name":"Wallace H. 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