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Nanoparticles, particularly those composed of gold, silver, and iron oxide, have emerged as promising candidates for changing cancer therapy. This comprehensive review demonstrates the landscape of nanoparticle\u2010based oncological interventions, focusing on the remarkable advancements and therapeutic potentials of gold, silver, and iron oxide nanoparticles. Gold nanoparticles have garnered significant attention for their exceptional biocompatibility, tunable surface chemistry, and distinctive optical properties, rendering them ideal candidates for various cancer diagnostic and therapeutic strategies. Silver nanoparticles, renowned for their antimicrobial properties, exhibit remarkable potential in cancer therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, and drug delivery enhancement. With their magnetic properties and biocompatibility, iron oxide nanoparticles offer unique cancer diagnosis and targeted therapy opportunities. This review critically examines the recent advancements in the synthesis, functionalization, and biomedical applications of these nanoparticles in cancer therapy. Moreover, the challenges are discussed, including toxicity concerns, immunogenicity, and translational barriers, and ongoing efforts to overcome these hurdles are highlighted. Finally, insights into the future directions of nanoparticle\u2010based cancer therapy and regulatory considerations, are provided aiming to accelerate the translation of these promising technologies from bench to bedside.<\/jats:p>","DOI":"10.1002\/adhm.202403059","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:28:38Z","timestamp":1730867318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-5339","authenticated-orcid":false,"given":"Priyanka","family":"Singh","sequence":"first","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark  Kogens Lyngby DK\u20102800 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-758X","authenticated-orcid":false,"given":"Santosh","family":"Pandit","sequence":"additional","affiliation":[{"name":"Systems and Synthetic Biology Division Department of Life Sciences Chalmers University of Technology  Gothenburg SE\u2010412 96 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Renukadevi","family":"Balusamy","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology Sejong University  Gwangjin\u2010Gu Seoul 05006 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukil","family":"Madhusudanan","sequence":"additional","affiliation":[{"name":"The Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark  Kogens Lyngby DK\u20102800 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences School of Medicine University of California  Riverside CA 92521 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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