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In combination with biological materials, cells and biological factors can provide a highly effective and safe treatment strategy for bone repair and regeneration, especially based on these multifunctional hydrogel interface materials. However, itis still a challenge to formulate hydrogel materials with fascinating properties (e.g., biological activity, controllable biodegradability, mechanical strength, excellent cell\/tissue adhesion, and controllable release properties) for their clinical applications in complex bone repair processes. In this review, we will highlight recent advances in developing functional interface hydrogels. We then discuss the barriers to \u00a0producing of functional hydrogel materials without sacrificing their inherent properties, and potential applications in cartilage and bone repair are discussed. Multifunctional hydrogel interface materials can serve as a fundamental building block for bone tissue engineering.<\/jats:p>","DOI":"10.1002\/adhm.202403079","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:06:00Z","timestamp":1736485560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Functional Hydrogel Interfaces for Cartilage and Bone Regeneration"],"prefix":"10.1002","volume":"14","author":[{"given":"Yucheng","family":"Cao","sequence":"first","affiliation":[{"name":"School of Environmental and Biological Engineering Nanjing University of Science and Technology  Nanjing 210094 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environmental and Biological Engineering Nanjing University of Science and Technology  Nanjing 210094 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