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Strategies that activate programmed cell death mechanisms and repolarized tumor\u2010associated macrophages toward an antitumoral M1\u2010like phenotype can help reverse the immunosuppressive tumor microenvironment. In this study, a novel approach using NIR\u2010II (1000\u20131700\u00a0nm) photoacoustic imaging (PAI)\u2010guided chemo\u2010photothermal therapy is presented. NIR\u2010II imaging, with its superior tissue penetration and reduced background noise, enables precise tumor targeting. A targeted nano prodrug is developed using poly (lactic\n                    <jats:italic>\u2010co<\/jats:italic>\n                    \u2010glycolic acid) nanoparticles loaded with A1094 dye and temozolomide (TMZ), coupled with an anti\u2010CD47 antibody. This system employs synergistic chemo\u2010photothermal therapy activated by NIR\u2010II light, inducing apoptosis, pyroptosis, and T\u2010cell activation. PAI provides rapid, point\u2010of\u2010care GBM diagnosis, and highlighted the effective targeting of the PA1094T nanoplatform. In a recurrent GBM model, the combination of PA1094T and anti\u2010CD47 antibody significantly enhances cancer cell phagocytosis and effectively remodels the immunosuppressive microenvironment, resulting in better therapeutic outcomes compared to conventional therapies. These results indicate that this NIR\u2010II PAI\u2010guided drug cocktail therapy is a promising strategy for treating GBM, potentially addressing drug resistance and improving treatment efficacy through enhanced targeting and immunomodulation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403108","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T05:14:51Z","timestamp":1732943691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["NIR\u2010II Photoacoustic Imaging\u2010Guided Chemo\u2010Photothermal Therapy Using PA1094T Combined with Anti\u2010CD47 Antibody: Activating Pyroptosis against Orthotopic Glioblastoma"],"prefix":"10.1002","volume":"14","author":[{"given":"Shiying","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan","family":"Lo","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"},{"name":"School of Medicine South China University of Technology  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijin","family":"Fan","sequence":"additional","affiliation":[{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojia","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1781-4612","authenticated-orcid":false,"given":"Liming","family":"Nie","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences  Guangzhou 510080 China"},{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 510080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2020.10.005"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03378"},{"key":"e_1_2_9_3_1","unstructured":"B.Liu H.Zhou L.Tan K. 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