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Periodontitis, a widespread bacterial infectious disease, is gaining attention. Current novel biomaterials address key clinical issues like bacterial infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti\u2010inflammatory, and tissue regeneration properties. However, strategies that integrate the advantages of these biomaterials to achieve synergistic therapeutic effects by clearing oral biofilms, inhibiting inflammation activation, and restoring periodontal soft and hard tissue functions remain very limited. Recent studies highlight the link between periodontitis and systemic diseases, underscoring the complexity of the periodontal disease. There is an urgent need to find comprehensive treatment plans that address clinical requirements. Whether by integrating new biomaterials to enhance existing periodontal treatments or by developing novel approaches to replace traditional therapies, these efforts will drive advancements in periodontitis treatment. Therefore, this review compares novel biomaterials with traditional treatments. It highlights the design concepts and mechanisms of these functional materials, focusing on their antibacterial, anti\u2010inflammatory, and tissue regeneration properties, and discusses the importance of developing comprehensive treatment strategies. This review aims to provide guidance for emerging periodontitis research and to promote the development of precise and efficient treatment strategies.<\/jats:p>","DOI":"10.1002\/adhm.202403206","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T02:16:52Z","timestamp":1738549012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["New Advances in Periodontal Functional Materials Based on Antibacterial, Anti\u2010Inflammatory, and Tissue Regeneration Strategies"],"prefix":"10.1002","volume":"14","author":[{"given":"Haoyue","family":"Wu","sequence":"first","affiliation":[{"name":"Department of International VIP Dental Clinic Tianjin Stomatological Hospital School of Medicine Nankai University  Tianjin 300041 China"},{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction  Tianjin 300041 China"},{"name":"Wenzhou Institute University of Chinese Academy of 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