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Accordingly, a double\u2010crosslinked hydrogel that combines polyethylene glycol (PEG)\u2010crosslinked carboxymethyl chitosan (CMC) with a hybrid decellularized extracellular matrix (dECM) is developed. The dECM, sourced from porcine adipose and cardiac tissues, processed using a supercritical fluid technique (scCO<jats:sub>2<\/jats:sub>\u2010EtOH) retains 1.5\u20135\u2010fold more angiogenic and adipogenic cytokines than that processed using traditional methods. This hybrid dECM\u2010based filler demonstrates excellent physical properties and injectability, with injection forces being significantly less than that for crosslinked hyaluronic acid (HA) fillers. Upon incubation at 37\u00a0\u00b0C, the storage modulus of the fillers increases substantially, eventually enhancing their moldability from additional crosslinking and the thermosensitive nature of collagen. Assessments in a UVB\u2010induced photoaging mouse model indicate that the material maintains superior shape stability, durability, and supports vascularized tissue regeneration, reduces inflammation, and enhances VEGF expression and ECM maturation more effectively compared with that using other fillers. These promising results suggest that the material can serve as a highly effective multifunctional solution for injectable regenerative medical applications and is well\u2010suited for potential clinical trials.<\/jats:p>","DOI":"10.1002\/adhm.202403213","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T05:52:31Z","timestamp":1742449951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Supercritical Fluid\u2010Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment"],"prefix":"10.1002","volume":"14","author":[{"given":"Seol\u2010Ha","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Seoul National University Boramae Hospital Seoul National University College of Medicine  Seoul 07061 Republic of Korea"},{"name":"Bio\u2010max Institute Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Jun","family":"Kang","sequence":"additional","affiliation":[{"name":"R&amp;D Center Medifab Co. 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