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Oxygen plays a critical role in the healing process of DFU wounds by promoting cell migration and neovascularization. However, clinical hyperbaric oxygen (HBO) therapy predominantly uses systemic oxygen administration, posing challenges in inadequate DFU local oxygen penetration and potential ectopic organs oxygen toxicity. To address these challenges, a strategy to encapsulate oxygen with lipid microbubbles (OMBs) and incorporate them into a body temperature\u2010sensitive heparin\u2010pluronic copolymer hydrogel (HP\/OMBs) have been developed. HP\/OMBs showed high biocompatibility both in vitro and in vivo. After in situ administration, oxygen can be released from HP\/OMBs to the local deep site of the DFU wounds under ultrasound (US) triggering. 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