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However, their development has been hindered by low sterilization efficiency. Here, this issue is addressed by designing a peptide hydrogel that assembles ordered metal\u2010organic framework (MOF) nanoparticles with photocatalytic bactericidal activity. Specifically, a short peptide, Nap\u2010Gly\u2010Phe\u2010Phe\u2010His (Nap\u2010GFFH), is used to induce the assembly of zinc\u2010imidazolate MOF (ZIF\u20108) into a hydrogel (NHZ gel). This innovative structure integrates three key features: 1) ZIF\u20108 nanoparticles are encapsulated within the hydrogel, overcoming their inherent brittleness, insolubility, and limited moldability; 2) the ordered ZIF\u20108 structure enhances charge transfer, enabling efficient generation of reactive oxygen species (ROS); and 3) ZIF\u20108 simultaneously improves the photocatalytic bactericidal efficiency and mechanical properties of the hydrogel. The NHZ gel demonstrates remarkable antibacterial performance, achieving &gt;99.9% and 99.99% inactivation of <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>, respectively, within 15 min of simulated solar radiation. Additionally, the NHZ gel exhibits excellent biocompatibility, water retention, and exudate absorption, highlighting its broad potential for wound healing.<\/jats:p>","DOI":"10.1002\/adhm.202403292","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T23:30:41Z","timestamp":1733441441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Peptide\u2010Induced Hydrogelation with Ordered Metal\u2010Organic Framework Nanoparticles Generating Reactive Oxygen Species for Integrated Wound Repair"],"prefix":"10.1002","volume":"14","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST)  Beijing 100190 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