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Such bleedings lead to numerous casualties in military confrontations, traffic accidents, and surgical injuries. Consequently, the rapid control of the bleedings, particularly for extensive and pressurized wounds, is crucial in first\u2010aid situations. In this work, a double\u2010layered bioadhesive patch that combines a superabsorbent adhesive hydrogel with a highly tough antibacterial polyurethane film, which is called as Bio\u2010Patch, is proposed. The Bio\u2010Patch demonstrates superior mechanical strength and forms robust bioadhesion to acute bleeding wounds. Furthermore, the Bio\u2010Patch enables protecting against external Gram\u2010negative and Gram\u2010positive bacteria. Thanks to the double\u2010layered structures having synergistic functions of stable barrier and robust adhesion, the Bio\u2010Patch provides optimal wound sealing (burst strength exceeding 310\u00a0mmHg) both in vitro and in vivo. It also demonstrates superior hemostatic effects (less than 30 s) in vivo. This offers promising opportunities for rapid control of extensive and pressurized hemorrhage in first\u2010aid clinical scenarios.<\/jats:p>","DOI":"10.1002\/adhm.202403412","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T09:31:39Z","timestamp":1731144699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bioadhesive First\u2010Aid Patch with Rapid Hemostasis and High Toughness Designed for Sutureless Sealing of Acute Bleeding Wounds"],"prefix":"10.1002","volume":"14","author":[{"given":"Ziyuan","family":"Zeng","sequence":"first","affiliation":[{"name":"Joint Laboratory of Advanced Biomedical Materials (NFU\u2010UGent) Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical Engineering Nanjing Forestry University (NFU)  Nanjing 210037 China"},{"name":"State Key Laboratory of Female Fertility Promotion Department of 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