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Therefore, the development of cascade structures that mimic the natural extracellular matrix (ECM), achieving both macro\u2010stability and micro\u2010structure, is of critical importance. This study proposes a novel, efficient, and general photo\u2010functionalization strategy for modifying natural biomaterials. Collagen microfibers obtained through electrospinning are functionalized with an active N\u2010Hydroxysuccinimide (NHS) ester, to impart light\u2010curing ability. This approach expands the construction of photo\u2010controllable hydrogel systems beyond conventional single methacrylate (MA) modifications or di\u2010tyrosine bonding, enabling integration with other biomaterials for comprehensive ECM remodeling. Subsequently, the collagen microfibers are then photo\u2010embedded into gelatin methacryloyl (GelMA) via covalent crosslinking to form a fibrous hydrogel, which supports both structural and functional requirements. In terms of biological functionality, the hydrogel promotes significant inward migration and retention of human corneal fibroblasts (hCFs), replicating ECM\u2010like environments. Furthermore, its excellent burst resistance suggests potential as a bioadhesive. In a rabbit model, the hydrogel achieved effective repair of large\u2010sized (6 mm) corneal defects, facilitates epithelial migration, and maintained long\u2010term stability. This work provides valuable guidance for designing efficient and simplified bioactive materials for corneal repair and broader tissue engineering applications.<\/jats:p>","DOI":"10.1002\/adhm.202403444","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:09:01Z","timestamp":1737943741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Photocontrolled Bionic Micro\u2010Nano Hydrogel System used Novel Functional Strategy for Cell Delivery and Large\u2010Scale Corneal Repair"],"prefix":"10.1002","volume":"14","author":[{"given":"Mingshan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Modern Optics Nankai University  Tianjin 300350 China"},{"name":"Nankai University Eye Institute Nankai University  Tianjin 300071 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