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Compared to traditional microbiota regulation methods, prebiotics and probiotics demonstrate significant advantages in terms of safety and patient adaptability. Their synergy not only improves the intestinal environment but also enhances the host's anti\u2010tumor immune response. 5\u2010Fluorouracil (5\u2010FU) is a first\u2010line chemotherapy drug that has a short half\u2010life and low bioavailability. However, if administered in an untargeted manner, 5\u2010FU also causes adverse reactions. Liposomes can improve the pharmacokinetic profile of drugs and provide targeted delivery to the tumor site, thereby reducing side effects. In this work, a 5\u2010FU\u2010loaded liposome is modified with the prebiotic xylan derivative Sxy and the probiotic <jats:italic>Akkermansia muciniphila<\/jats:italic> active phospholipid homolog 1,2\u2010dipalmitoylphosphatidy\u2010lethanolamine (DPPE) to construct FLSK. The latter effectively prolongs the intestinal transport and release of 5\u2010FU, maintaining high drug concentrations at the tumor site. FLSK is found to inhibit tumor growth and significantly extends the survival period of mice. In addition, FLSK promotes anti\u2010tumor immunity and regulation of the gut microbiota. Combining the merits of prebiotics and probiotics, FLSK provides a potential strategy for integrating chemotherapy with gut microbiota regulation therapy for the treatment of CRC.<\/jats:p>","DOI":"10.1002\/adhm.202403587","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T02:02:25Z","timestamp":1734314545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["5\u2010Fluorouracil Loaded Prebiotic\u2013Probiotic Liposomes Modulating Gut Microbiota for Improving Colorectal Cancer Chemotherapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Xujie","family":"Sun","sequence":"first","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"},{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Shan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyan","family":"He","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Liu","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research &amp; Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0136-3132","authenticated-orcid":false,"given":"Tianqun","family":"Lang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i18.1946"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2018.16.3.338"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184584"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494052"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01406-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12069"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.12.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.01.071"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003363"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5101423"},{"key":"e_1_2_8_12_1","first-page":"235","volume":"78","author":"Silva Borges D.","year":"2020","journal-title":"Nutr. 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