{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:35:10Z","timestamp":1770597310293,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20260 22075209 52303155"],"award-info":[{"award-number":["U20A20260 22075209 52303155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0104000"],"award-info":[{"award-number":["2024YFE0104000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sepsis is an underappreciated yet severe threat to human life, marked by organ dysfunction and high mortality resulting from disordered inflammatory responses to blood infection. Unfortunately, no specific drugs are available for effective sepsis treatment. As a pivotal biomarker for sepsis, lactate levels are closely related to vascular permeability and sepsis\u2010associated mortality. Herein, a dual\u2010pipeline lactate removal strategy is reported from circulating blood to ameliorate vascular permeability and lipopolysaccharide (LPS)\u2010induced sepsis. This is achieved by formulating lactate oxidase (LOX)\u2010encapsulated hollow manganese dioxide (HMnO\n                    <jats:sub>2<\/jats:sub>\n                    ) nanohybrids (LOX@HMnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010P[5]A) bearing pillar[5]arene (P[5]A) macrocycle with excellent host\u2010guest properties. The highly biocompatible nanohybrids enable direct lactate consumption through LOX catalytic degradation and block lactate production by P[5]A\u2010mediated LPS trapping, allowing for dual\u2010pipeline lactate removal to maximize the reversal of lactate\u2010mediated vascular hyperpermeability. Besides, HMnO\n                    <jats:sub>2<\/jats:sub>\n                    cores decompose hydrogen peroxide produced from lactate oxidation into oxygen, further contributing to lactate consumption and mitigating the hypoxic inflammatory environment. In vivo investigations demonstrate that intravenous administration of LOX@HMnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010P[5]A nanohybrids with extended blood circulation can effectively ameliorate endothelial barrier dysfunction, inflammatory responses, and multiple organ injury, ultimately improving survival outcomes in LPS\u2010induced sepsis. Taken together, this dual\u2010pipeline lactate removal strategy offers a promising approach for efficient sepsis treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403592","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:55:57Z","timestamp":1738306557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Dual\u2010Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide\u2010Induced Sepsis"],"prefix":"10.1002","volume":"14","author":[{"given":"Shuangfeng","family":"Ge","sequence":"first","affiliation":[{"name":"State Key Laboratory of Separation Membranes and Membrane Processes &amp; Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) &amp; Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes School of Materials Science and Engineering Tiangong University  Tianjin 300387 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing\u2010Huo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Sustainable Energy and Resources College of Chemistry and Chemical Engineering Qingdao University  308 Ningxia Road Qingdao 266071 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juntao","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Separation Membranes and Membrane Processes &amp; Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) &amp; Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes School of Materials Science and Engineering Tiangong University  Tianjin 300387 P. R. 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