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The development of antimicrobial coatings for medical devices has emerged as a promising strategy. However, limited biological functionality and the incompatibility between bactericidal properties and biosafety remain great challenges. Herein, a multifunctional polymer coating (CPB\u2010Ac) is created, incorporating an ultrasonic\u2010responsive carbon monoxide release unit (CORM\u2010Ac) and antifouling unit to treat catheter\u2010related complications. As\u2010synthesized CPB\u2010Ac polymer can be stably anchored to various medical devices with arbitrary shapes and compositions via facile UV treatment. Both in vivo and vitro experiments demonstrated that this multi\u2010functional coating exhibits anti\u2010fouling, anti\u2010inflammatory, and broad\u2010spectrum antibacterial activities as well as good biosafety. During the initial implantation phase, the antifouling units of CPB\u2010Ac coating effectively inhibit the attachment of biological contaminants, significantly reducing the risk of thrombosis and bacterial infection. Once bacterial infection occurs, ultrasonic irradiation can activate CPB\u2010Ac coating to release CO with a much higher amount of 55.3 \u00b5<jats:sc>m<\/jats:sc> than non\u2010ultrasound controls, therefore rapidly eliminating bacteria and alleviating inflammatory response. It is believed that the work may provide an effective method for the development of next\u2010generation intelligent medical coatings against catheter\u2010related complications.<\/jats:p>","DOI":"10.1002\/adhm.202403597","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T03:56:22Z","timestamp":1735790182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ultrasound\u2010Controllable Release of Carbon Monoxide in Multifunctional Polymer Coating for Synergetic Treatment of Catheter\u2010Related Infections"],"prefix":"10.1002","volume":"14","author":[{"given":"Ziqing","family":"Liang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 P. R. 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