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Biomarker concentrations and trends may imply individual susceptibility, symptom classification, and the specific progression of MS. It is therefore essential to explore biosensors capable of providing sensitive, accurate, and real\u2010time monitoring of biomarkers. This review provides a summary of the pathogenesis and biological pathways underlying MS, followed by an examination of biomarkers and their research progress. The most recent electrochemical biosensors developed for the non\u2010invasive detection of representative biomarkers (e.g., cortisol, \u03b1\u2010amylase, and estrogen) are comprehensively summarized. The effectiveness of these biosensors in practical application is discussed. 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