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Current treatments, including mechanical debridement and antibiotics, often fail to eradicate recalcitrant biofilms and mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long\u2010term treatment outcomes. To address these limitations, an injectable nanoenzyme hydrogel composed of a dopamine (DA)\u2010modified hyaluronic acid (HA) scaffold and a graphdiyne\u2010iron (GDY\u2010Fe) complex, named GDY\u2010Fe@HA\u2010DA, exhibits excellent tissue adhesion, self\u2010healing, antibacterial properties, and biocompatibility. Under near\u2010infrared laser irradiation, GDY\u2010Fe@HA\u2010DA effectively eradicates a variety of pathogens, including\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , through a synergistic combination of chemodynamical and photothermal therapies. The hydrogel's efficacy is further validated in both bacterial\u2010infected skin wounds and rat periodontitis models. It effectively alleviates the inflammatory environment and promotes wound healing and periodontal tissue recovery. This findings highlight the potential of GDY\u2010Fe@HA\u2010DA as a promising therapeutic material for periodontitis and other tissue injuries.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403683","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T03:05:17Z","timestamp":1734663917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A Microenvironment\u2010Responsive Graphdiyne\u2010Iron Nanozyme Hydrogel with Antibacterial and Anti\u2010Inflammatory Effect for Periodontitis Treatment"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiaojie","family":"Wu","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of Education Inner Mongolia University  235 Daxue West Street Hohhot 010021 P. R. 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