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This work demonstrates the fabrication of high frequency and wide bandwidth transducers with fluoropolymer and highly polarizing cubic single crystal Barium titanate (BaTiO<jats:sub>3<\/jats:sub>) ceramic composite for high resolution in\u2010vivo photo\u2010acoustic and ultrasound imaging. For transducer fabrication, a customized bio\u2010compatible nanocomposite sensor film of PVDF\u2010TrFE (Polyvinylidene fluoride trifluoroethylene)\/BaTiO<jats:sub>3<\/jats:sub> (BTO) is synthesized by drop and dry in heating\u2010cum\u2010electro\u2010poling system for advancing polarization, crystallinity, and higher charge generation. The ratio of nanofiller cubic single crystal BTO and PVDF\u2010TrFE is optimized using characterization techniques such as FTIR, XRD and electrometer. Thereafter, SEM and TGA analyses are performed to study the surface morphology and thermal stability of the sensing film. Transducers with central frequencies varying from 17 to 42MHz are fabricated and tested for both pulse\u2010echo mode and receiving photoacoustic signals. These transducers are used for sensing photoacoustic signals generated from hemoglobin and eumelanin and further for ultrasound and photoacoustic imaging. The imaging results are compared with the results obtained using a commercial ultrasound and photoacoustic imaging device. To the best of the knowledge and available literature, for the first time, the fabrication of ultrasound\/photoacoustic transducers with cubic single\u2010crystal nanofiller and fluoropolymer nanocomposite is showed. The detailed transducer fabrication method, characterization results, and imaging of biological tissue using photoacoustic and ultrasound are presented.<\/jats:p>","DOI":"10.1002\/adhm.202403711","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T02:34:42Z","timestamp":1738118082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fluoropolymer\u2010Single Crystal Nanocomposite Based Transducer Fabrication for Bio\u2010Imaging"],"prefix":"10.1002","volume":"14","author":[{"given":"Nagendra","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Physical Sciences Indian Institute of Science Education and Research Mohali Knowledge City, Sector 81, SAS Nagar Manauli 140306 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2087-8112","authenticated-orcid":false,"given":"S K","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences Indian Institute of Science Education and Research Mohali Knowledge City, Sector 81, SAS Nagar Manauli 140306 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1483"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2019.11.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2014.04.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2019.100141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2014.06.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/58.852073"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/58.883525"},{"key":"e_1_2_8_9_1","first-page":"11","volume":"9","author":"Xu F.","year":"2018","journal-title":"Micromachines"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pen.24088"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114-021-00217-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.measurement.2019.04.050"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1143\/JJAP.8.975"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12391-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.157"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b02172"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20662-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.41667"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.23443"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100986"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22663-6"},{"key":"e_1_2_8_22_1","first-page":"6","volume":"11","author":"Xie L.","year":"2021","journal-title":"Crystals"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901287"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2020.104706"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002100"},{"key":"e_1_2_8_26_1","first-page":"5","volume":"8","author":"Hu Y.","year":"2018","journal-title":"Appl. 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