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This work investigates porous silicon dioxide (pSiO\n                    <jats:sub>2<\/jats:sub>\n                    ) microparticles as a delivery vehicle for progestins via melt\u2010infiltration of drugs into the mesopores. The pSiO\n                    <jats:sub>2<\/jats:sub>\n                    is prepared through electrochemical anodization of single\u2010crystalline silicon followed by thermal oxidation, yielding vertically oriented pores (\u224850\u00a0nm diameter) with porosity varied (between 35\u201375%) to optimize drug loading and release. Among the progestins tested, etonogestrel and levonorgestrel (LNG) decompose near their melting points, preventing melt infiltration. However, addition of 20% cholesterol by mass suppresses the melting point of LNG sufficiently to enable loading without degradation. Mass loadings exceeding 50% (drug: drug + carrier) are achieved for segesterone acetate (SEG) and LNG, retaining drug crystallinity as confirmed by X\u2010ray diffraction. In vitro, both SEG and LNG\u2010loaded pSiO\n                    <jats:sub>2<\/jats:sub>\n                    display sustained drug release for up to 3 months, with reduced burst release, more constant steady\u2010state concentrations, and a substantially reduced tail compared to pure LNG or SEG, or SEG loaded into pSiO\n                    <jats:sub>2<\/jats:sub>\n                    from a chloroform solution. In a pilot in vivo study, SEG\u2010loaded pSiO\n                    <jats:sub>2<\/jats:sub>\n                    microparticles are well tolerated in 20\u2010week\u2010old female rats over a 25\u2010week period, with no signs of toxicity.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403802","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T05:56:51Z","timestamp":1739512611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-0771","authenticated-orcid":false,"given":"Geoffrey","family":"Hollett","sequence":"first","affiliation":[{"name":"Materials Science &amp; Engineering Program University of California  San Diego, 9500 Gilman Drive La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-849X","authenticated-orcid":false,"given":"Ruhan","family":"Fan","sequence":"additional","affiliation":[{"name":"Materials Science &amp; 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