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However, the instability resulting from their intrinsic membrane\u2010free nature restricts the application of coacervates in drug delivery. Herein, the engineering of poly(ethylene glycol) nanoparticles (PEG NPs) is reported using coacervates composed of PEG and polyphenols as the templates, where PEG is subsequently cross\u2010linked based on different chemistries (e.g., thiol\u2010disulfide exchange, click chemistry, and Schiff base reaction). The reported assembly strategy avoids the template removal process and the resultant PEG NPs exhibit excellent stability in the physiological environment compared to coacervates. The presence of polyphenols in PEG NPs enables the loading of various cargos including metal ions (i.e., Ru, Gd, Mn, Fe) and drug molecules (i.e., doxorubicin), which demonstrates their promise in magnetic resonance imaging and combinational tumor therapy. This work provides a promising strategy to promote the development of coacervate\u2010derived NPs as a drug delivery system for biomedical applications.<\/jats:p>","DOI":"10.1002\/adhm.202403865","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T02:40:46Z","timestamp":1735872046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Coacervate\u2010Derived Assembly of Poly(ethylene glycol) Nanoparticles for Combinational Tumor Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Hanru","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University  Jinan Shandong 250100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid 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