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Despite local therapeutic interventions remaining the primary mode of treatment, the dynamic nature of the oral cavity, characterized by continuous muscular activity and salivary secretion, poses barriers to sustained drug retention and thereby limits therapeutic efficacy. To address this issue, an approach has been devised that aims to facilitate transdermal delivery of bioactive components to promote the healing of diabetic oral ulcers. A multifunctional soluble microneedle (MN) patch is prepared using \u03b3\u2010polyglutamic acid (\u03b3\u2010PGA), which is loaded with quercetin (Qu)\u2010modified Mg\u2212Zn layered hydroxide salt (LHS) nanosheets (LHSQ) with anti\u2010inflammatory, antimicrobial and pro\u2010angiogenic bioactivities to combat the diabetic oral ulcers. These findings demonstrate that the LHSQ\u2010loaded MN (LHSQ\u2010MN) patches are capable of effectively penetrating the oral mucosa. In a rat model of diabetic oral ulcers, the application of LHSQ\u2010MN patches is found to facilitate the establishment of regeneration sites, regulate the inflammatory microenvironment of damaged tissues, exhibit potent antibacterial effects, expedite the reconstitution of the mucosal epithelium, and accelerate ulcer healing through the promotion of angiogenesis. These outcomes highlight the potential of LHSQ\u2010MN patches as a promising therapeutic strategy for the management of oral ulcers in diabetic patients.<\/jats:p>","DOI":"10.1002\/adhm.202403883","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T02:16:36Z","timestamp":1739240196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Polyphenol\u2010Modified Mg\u2212Zn Layered Hydroxide\u2010Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment"],"prefix":"10.1002","volume":"14","author":[{"given":"Haibo","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital &amp; School of Stomatology Fudan University  Shanghai 201102 P. R. 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