{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:19:14Z","timestamp":1786976354282,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chemotherapy\u2010induced premature ovarian insufficiency (POI) is a major cause of infertility and hormonal imbalance in young female cancer survivors. In this study, developed a biomimetic scaffold is developed that incorporates polydeoxyribonucleotide (PDRN) and melatonin to restore ovarian function. The scaffold is designed to mimic the ovarian extracellular matrix (ECM), enhancing angiogenesis, promoting antioxidant effects, and reducing reactive oxygen species (ROS). Human embryonic stem cell\u2010derived mesenchymal progenitor cells (hESC\u2010MPCs) are also incorporated to further support tissue regeneration. The scaffold demonstrated strong efficacy in improving cell survival, promoting folliculogenesis, and restoring ovarian function in a chemotherapy\u2010induced perimenopausal mouse model. Results showed that the scaffold enhanced vascularization, reduced fibrosis, and normalized hormone levels, including estrogen (E\n                    <jats:sub>2<\/jats:sub>\n                    ) and anti\u2010M\u00fcllerian hormone (Amh). Additionally, the transplantation of the scaffold restored fertility rates and increased the number of offspring in treated mice. This approach presents a promising solution for improving ovarian recovery and fertility preservation in patients with chemotherapy\u2010induced POI, offering a novel therapeutic strategy for reproductive health.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202403944","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T01:52:07Z","timestamp":1744336327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ovarian Function Restoration with Biomimetic Scaffold Incorporating Angiogenic Molecules and Antioxidant in Chemotherapy\u2010Induced Perimenopausal Model"],"prefix":"10.1002","volume":"14","author":[{"given":"Da\u2010Seul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Science CHA University  Seongnam\u2010si Gyeonggi\u2010do 13488 Republic of Korea"},{"name":"Division of Engineering in Medicine Department of Medicine Harvard Medical 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