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In many scenarios, it is desirable for the embolic to distally penetrate to the level of the microvasculature, which maximizes devascularization. Existing agents exhibit inconsistent distal penetration and have other limitations including tendency for proximal reflux, patient pain during infusion, lack of fluoroscopic radiopacity, potential for catheter adhesion, susceptibility to recanalization, and other usability challenges. NeoCast is an in situ curing, solvent\u2010free, non\u2010adhesive biomaterial composed of polydimethylsiloxane, bismuth trioxide, and fumed silica that possesses shear\u2010responsive properties enabling manual injectability through commercially\u2010available microcatheters with large and small diameter lumens. Here, embolization performance with and without flow arrest, in both arterial and venous preclinical anatomies is reported. NeoCast reproducibly achieves a rate of distal penetration with microvascular occlusion that is superior to existing agents, exhibits excellent fluoroscopic visibility, and provides durable occlusion. There is mild inflammation when NeoCast is infused into blood vessels and absence of neurotoxicity when implanted directly into brain tissue. The engineered NeoCast material is poised to become a next\u2010generation, liquid embolic agent for applications in which distal microvascular occlusion is desired.<\/jats:p>","DOI":"10.1002\/adhm.202404011","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T04:40:32Z","timestamp":1741668032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An In Situ Curing, Shear\u2010Responsive Biomaterial Designed for Durable Embolization of Microvasculature"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0263-0634","authenticated-orcid":false,"given":"Quynh P.","family":"Pham","sequence":"first","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Jeffrey V.","family":"Groom","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-9785","authenticated-orcid":false,"given":"Chander","family":"Sadasivan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stony Brook Medicine  101 Nicolls Road Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-8780","authenticated-orcid":false,"given":"David J.","family":"Fiorella","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Stony Brook Medicine  101 Nicolls Road Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3461-437X","authenticated-orcid":false,"given":"David C.","family":"Madoff","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Yale University  333 Cedar St. New Haven CT 06510 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee\u2010Jae","family":"Guo","sequence":"additional","affiliation":[{"name":"CBSET, Inc  500 Shire Way Lexington MA 02421 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fornaciari","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Guertin","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Wiltsey","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Core","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Merlo","sequence":"additional","affiliation":[{"name":"Arsenal Medical, Inc  100 Beaver Street, Suite 302 Waltham MA 02453 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wustenberg","sequence":"additional","affiliation":[{"name":"Mycroft Medical LLC  20828 Ahern Blvd. Farmington MN 55024 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Virmani","sequence":"additional","affiliation":[{"name":"CVPath Institute Inc  19 Firstfield Rd. 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